Marie Curie Initial Training Network

Xiao-nong Wang

Dr Xiao-nong Wang
Lecturer in Cellular Therapies
Haematological Sciences
Institute of Cellular Medicine
The Medical School
Newcastle University
Newcastle Upon Tyne

Dr Wang's research focuses on cellular therapeutic interventions including recent studies on the roles of regulatory T cells and mesenchymal stromal cells in haematopoietic stem cell transplantation and regenerative medicine. A common aim of Dr Wang's research is to identify risk factors, predict responsiveness, improve safety and optimise therapeutic efficacy with an ultimate goal to reduce therapy-related mortality and morbidity hence improving the overall outcome of the cellular therapy.

Dr Wang currently supervises five PhD student, including one of the Celleurope Early Stage Researchers working on the project, “Use of mesenchymal stromal cells as a therapy for graft-versus-host disease and regenerative medicine”.


Relevant References

1. E Mavin, S Ahmed, G O'Boyle, B Turner, S Douglass, J Norden, M Collin, S Ali, AM Dickinson and XN Wang. Regulatory T cells inhibit CD8+ T cell tissue invasion in human skin GVH reactions. Transplantation 2012, 94:456-464

2. E Mavin, AM Dickinson, XN Wang. Do Cryopreserved regulatory T cells retain their suppressive potency? Transplantation 2013

3. XN Wang, M Haniffa, U Holtick, M Collin, G Jackson, C Hilkens, E Holler, M Edinger, P Hoffmann and AM Dickinson. Natural regulatory T cell suppression of human CD8+ T cell mediated graft-versus-host reaction requires their presence during priming. Transplantation 2009, 88:188-197

4. XN Wang*, M Winter*, W Daubener, A Eyking, M Rae, AM Dickinson, P Wernet, G Kogler and RV Sorg. Suppression of Cellular Immunity by Cord Blood-Derived Unrestricted Somatic Stem Cells is Cytokine Dependent. J Cell Mol Med 2009, 13:2465-2475.

5. AM Dickinson, XN Wang, L Sviland, FA Vyth-Dreese, GH Jackson, T Schumacher, J Haanen, T Mutis and E Goulmy. In situ dissection of graft-versus-host and graft-versus-leukemia effects by minor histocompatibility antigen specific cytotoxic T cells. Nature Medicine 2002, 8: 410-415