Celleurope
Marie Curie Initial Training Network

Publications


Pearce KF1, Balavarca Y2, Norden J1, Jackson G3, Holler E4, Dressel R5, Greinix H6, Toubert A7, Gluckman E8, Hromadnikova I9, Sedlacek P10, Wolff D4, Holtick U11, Bickeböller H2, Dickinson AM1. Impact of genomic risk factors on survival after haematopoietic stem cell transplantation for patients with acute leukaemia. Int J Immunogenet. 2016 Dec;43(6):404-412. doi: 10.1111/iji.12295. https://www.ncbi.nlm.nih.gov/pubmed/27870355

 

E M Weissinger, C Human, J Metzger, L Hambach et al. The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation. Leukemia advance online publication 4 November 2016; doi: 10.1038/leu.2016.259. http://www.nature.com/leu/journal/vaop/ncurrent/full/leu2016259a.html

 

Margherita Boieri, 1,2 Pranali Shah,3 Ralf Dressel,3 and Marit Inngjerdingen1,2,* The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview. Front Immunol. 2016; 7: 333.Published online 2016 Aug 30. doi: 10.3389/fimmu.2016.00333. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003882/

 

Vaupel P, Multhoff G. Adenosine can thwart antitumor immune responses elicited by radiotherapy : Therapeutic strategies alleviating protumor ADO activities.Strahlenther Onkol. 2016 May;192(5):279-87. doi: 10.1007/s00066-016-0948-1. https://www.ncbi.nlm.nih.gov/pubmed/26961686

 

Shevtsov M, Multhoff G. Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.Front Immunol. 2016 Apr 29;7:171. doi: 10.3389/fimmu.2016.00171. https://www.ncbi.nlm.nih.gov/pubmed/27199993

 

Isernhagen A1, Schilling D2,3, Monecke S1,4, Shah P1, Elsner L1, Walter L5,4, Multhoff G2,3, Dressel R6,7. The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA. Immunogenetics. 2016 Feb;68(2):109-23. doi: 10.1007/s00251-015-0884-8. http://link.springer.com/article/10.1007%2Fs00251-015-0884-8

 

Isernhagen A, Schilling D, Monecke S, Shah P, Elsner L, Walter L, Multhoff G, Dressel R. The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA. Immunogenetics. (2016) Feb;68(2):109-23. http://www.ncbi.nlm.nih.gov/pubmed/26585323

 

Isernhagen A1, Schilling D2,3, Monecke S1,4, Shah P1, Elsner L1, Walter L5,4, Multhoff G2,3, Dressel R6,7. The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA. Immunogenetics. 2016 Feb;68(2):109-23. doi: 10.1007/s00251-015-0884-8. http://link.springer.com/article/10.1007%2Fs00251-015-0884-8

 

Combs SE, Schmid TE, Vaupel P, Multhoff G. Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts.Cancers (Basel). 2016 Jan 13;8(1). pii: E15. doi: 10.3390/cancers8010015. https://www.ncbi.nlm.nih.gov/pubmed/26771644

 

Sage EK, Schmid TE, Sedelmayr M1, Gehrmann M1, Geinitz H, Duma MN, Combs SE, Multhoff G. Comparative analysis of the effects of radiotherapy versus radiotherapy after adjuvant chemotherapy on the composition of lymphocyte subpopulations in breast cancer patients. Radiother Oncol. 2016 Jan;118(1):176-80. doi: 10.1016/j.radonc.2015.11.016. https://www.ncbi.nlm.nih.gov/pubmed/26683801

 

Dasaradha Jalapothu, Margherita Boieri, Rachel E. Crossland, Pranali Shah, Isha A. Butt,Jean Norden, Ralf Dressel, Anne M. Dickinson, and Marit Inngjerdingen. Tissue-Specific Expression Patterns of MicroRNA during Acute Graft-versus-Host Disease in the Rat. Front Immunol. 2016; 7: 361. doi: 10.3389/fimmu.2016.00361. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025478/

 

Shevtsov M and Multhoff G (2016) Immunological and Translational Aspects of NK Cell-Based Antitumor Immunotherapies. Front. Immunol. 7:492. doi: 10.3389/fimmu.2016.00492. http://journal.frontiersin.org/article/10.3389/fimmu.2016.00492/full

 

D Weber , PJ Oefner , K Dettmer , A Hiergeist , J Koestler , A Gessner , M Weber , F Stämmler5 , J Hahn , D Wolff , W Herr and E Holler. Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantationBone Marrow Transplantation (2016) 51, 1087–1092; doi:10.1038/bmt.2016.66. http://www.nature.com/bmt/journal/v51/n8/pdf/bmt201666a.pdf

 

Hromadnikova I, Li S, Kotlabova K,Dickinson AM (2016). Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp 70 Derived 14-Mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors on Peripheral Blood T Cells, B Cells and NKT Cells. PLoS ONE 11 (3): e0151535. doi:10.1371/journal.pone.0151535.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151535

 

Atarod S, Ahmed MM, Lendrem C, Pearce KF, Cope W, Norden J, Wang X-N, Collin M and Dickinson AM (2016). miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence. Front. Immunol. 7:56. http://dx.doi.org/10.3389/fimmu.2016.00056

 

Mozes P, HauserP, Hortobagyi T, Benyo G, Petak I, Garami M, Cserhati A, Bartyik K, BognaL, Nagy Z, Turanyi E, Hideghety K. Evaluation of the good tumor response of embryonal tumor with abundant neuropil and true rosettes (ETANTR). J Neurooncol (2016) 126:99–105 https://sciencescape.org/paper/191560555

 

Isernhagen A, Malzahn D, Bickeböller H and Dressel R (2016) Impact of the MICA- 129Met/Val Dimorphism on NKG2D-Mediated Biological Functions and Disease Risks. Front. Immunol. 7:588. doi: 10.3389/fimmu.2016.00588. http://journal.frontiersin.org/article/10.3389/fimmu.2016.00588/full

 

Reis M, Ogonek J, Qesari M, Borges NM, Nicholson L, Preußner L, Dickinson AM, Wang X-n, Weissinger EM and Richter A (2016) Recent Developments in Cellular Immunotherapy for HSCT-Associated Complications. Front. Immunol. 7:500. doi: 10.3389/fimmu.2016.00500. http://journal.frontiersin.org/article/10.3389/fimmu.2016.00500/full

 

Juric MK, Ghimire S, Ogonek J, Weissinger EM, Holler E, van Rood JJ, Oudshoorn M, Dickinson A and Greinix HT (2016) Milestones of Hematopoietic Stem Cell Transplantation – From First Human Studies to Current Developments. Front. Immunol. 7:470. doi: 10.3389/fimmu.2016.00470. http://journal.frontiersin.org/article/10.3389/fimmu.2016.00470/full

 

Gunther S, Ostheimer C, Stangl S, Specht HM, Mozes P, Jesinghaus M, Vordermark D, Combs SE, Peltz F, Jung MP, Multhoff G. Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer. Front Immunol. 2015 Nov 2;6:556. doi: 10.3389/fimmu.2015.00556. https://www.ncbi.nlm.nih.gov/pubmed/26579130

 

Schilling D, Kühnel A, Konrad S, Tetzlaff F, Bayer C, Yaglom J, Multhoff G. Sensitizing tumor cells to radiation by targeting the heat shock response. Cancer Lett. 2015 May 1;360(2):294-301. doi: 10.1016/j.canlet.2015.02.033. https://www.ncbi.nlm.nih.gov/pubmed/25721082

 

Crossland RE, Norden J, Bibby LA, Davis J, Dickinson AM. Evaluation of optimal extracellular vesicle small RNA isolation and qRT-PCR normalisation for serum and urine. J Immunol Methods. 2016 Feb;429:39-49. doi: 10.1016/j.jim.2015.12.011. https://www.ncbi.nlm.nih.gov/pubmed/26723490

 

Atarod S, Smith H, Dickinson A and Wang XN. MicroRNA levels quantified in whole blood varies from PBMCs [version 4; referees: 2 approved, 1 not approved]. F1000Research 2015, 3:183. https://f1000research.com/articles/3-183/v4

 

Pockley, A.G., Foulds, G.A., Oughton, J.A., Kerkvliet, N.I., andMulthoff, G. 2015. Immune cell phenotyping using flow cytometry.Curr. Protoc. Toxicol. 66:18.8.1-18.8.34.doi: 10.1002/0471140856.tx1808s66. http://onlinelibrary.wiley.com/doi/10.1002/0471140856.tx1808s66/abstract

 

Pockley, A.G., Foulds, G.A., Oughton, J.A., Kerkvliet, N.I., andMulthoff, G. 2015. Immune cell phenotyping using flow cytometry.Curr. Protoc. Toxicol. 66:18.8.1-18.8.34.doi: 10.1002/0471140856.tx1808s66. http://onlinelibrary.wiley.com/doi/10.1002/0471140856.tx1808s66/abstract

 

Mathias Gehrmann, Michael Molls, Jun Itami and Gabriele Multhoff (2015). Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles. International Journal of Nanomedicine :10(1), 5687-5700. http://dx.doi.org/10.2147/IJN.S87174

 

SS Ahmed, XN Wang, J Norden, K Pearce, E El-Gezawy, S Atarod, I Hromadnikova, M Collin, E Holler and AM Dickinson (2015). Identification and validation of biomarkers associated with acute and chronic graft versus host disease. Bone Marrow Transplantation. 50, 1563-1571; doi:10.1038/bmt.2015.191. http://www.nature.com/bmt/journal/v50/n12/full/bmt2015191a.html

 

Balavarca Y, Pearce K, Norden J, Collin M, Jackson G, Holler E, Dressel R, Kolb H-J,Greinix H, Socie G, Toubert A, Rocha V, Gluckman E, Hromadnikova I, Sedlacek P,Wolff D, Holtick U, Dickinson A and Bickeböller H. Predicting survival using clinical risk scores and non-HLA immunogenetics. Bone Marrow Transplantation (2015) 50, 1445–1452 http://www.nature.com/bmt/journal/v50/n11/full/bmt2015173a.html

 

Weber D, Oefner P.J, Hiergeist A, Koestler J, AGessner A, Weber M, Hahn J, Wolff D, Stämmler F, Spang R, Herr W, Dettmer K, and Holler E.Low urinary indoxyl sulfate levels early after ASCT reflect a disrupted microbiome and are associated with poor outcome. http://dx.doi.org/10.1182/blood-2015-04-638858

 

Murakami N, Kühnel A, Schmid T-E, Ilicic K, Stangl S, Braun I.S, Gehrmann M, Molls M, Itami J, Multhoff G. Role of membrane Hsp70 in radiation sensitivity of tumor cells. Radiation Oncology (2015) 10:149 http://ro-journal.biomedcentral.com/articles/10.1186/s13014-015-0461-1#Abs1

 

Sadaf Atarod, Brie Turner, Kim Frances Pearce, Shaheda S. Ahmed, Jean Norden, Katarzyna Bogunia-Kubik, Xiao-nong Wang, Matthew Collin, Anne Mary Dickinson (2015). Elevated level of HSPA1L mRNA correlates with graft-versus-host disease. Transplant Immunol. 32(3):188-194. doi:10.1016/j.trim.2015.02.002 http://www.sciencedirect.com/science/article/pii/S0966327415000064

 

Specht HM, Ahrens N, Blankenstein C, Duell T, Fietkau R, Gaipl US, Günther C, Gunther S, Habl G, Hautmann H, Hautmann M, Huber RM, Molls M, Offner R, Rödel C, Rödel F, Schütz M, Combs SE and Multhoff G (2015). Heat shock protein 70 (Hsp70) peptide activated Natural Killer (NK) cells for the treatment of patients with non-small cell lung cancer (NSCLC) after radiochemotherapy (RCTx) - from preclinical studies to a clinical phase II trial. Front. Immunol. 6:162. doi: 10.3389/fimmu.2015.00162. http://journal.frontiersin.org/article/10.3389/fimmu.2015.00162/abstract

 

Greinix H, Kuzmina Z , Weigl R, Körmoczi U, Rottal A,Wolff D, KraljM, Kalhs P, Mitterbauer M, Rabitsch W,Edinger M, Holler E, Pickl W F. CD19+CD21low B-cells and CD4+CD45RA+CD31+ T-cells correlate with first diagnosis of chronic graft-versus-host disease. Biol Blood Marrow Transplant 21 (2015) 250-258. http://www.sciencedirect.com/science/article/pii/S108387911400682X

 

Daniela Schilling & Fabian Tetzlaff & Sarah Konrad &Wei Li & Gabriele Multhoff (2015). A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells. Cell Stress and Chaperones. 20: 1, 139-147http://link.springer.com/article/10.1007/s12192-014-0532-5

 

Theiss-Suennemann, J., Jörß, K., Messmann, J. J., Reichardt, S. D., Montes-Cobos, E., Lühder, F., Tuckermann, J. P., AWolff, H., Dressel, R., Gröne, H.-J., Strauß, G. and Reichardt, H. M. (2015), Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8+ T cells. J. Pathol., 235: 646–655. http://onlinelibrary.wiley.com/doi/10.1002/path.4475/abstract

 

Schilling D, Kühnel A, Tetzlaff F,S Konrad S, Multhoff G. NZ28-induced inhibition of HSF1, SP1 and NF-?B triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Cancer Immunol Immunother (2015) 64:599–608. http://www.medscape.com/medline/abstract/25854583

 

Breuninger et al. Quantitative Analysis of Liposomal Heat Shock Protein 70 (Hsp70) in the Blood of Tumor Patients Using a Novel LipHsp70 ELISA. J Clin Cell Immunol (2014) 5:5 http://www.omicsonline.org/open-access/quantitative-analysis-of-liposomal-heat-shock-protein-hsp-in-the-blood-of-tumor-patients-2155-9899-5-264.pdf

 

A. Graham Pockley, Brian Henderson and Gabriele Multhoff. Extracellular cell stress proteins as biomarkers of human disease (2014). Biochem. Soc. Trans. 42, 1744-1751; doi:10.1042/BST20140205 https://www.researchgate.net/publication/268451194_Extracellular_cell_stress_proteins_as_biomarkers_of_human_disease

 

Borchers S, Ogonek J, Varanasi PR, Tischer S, Bremm M, Eiz-Vesper B, Koehl U, Weissinger EM (2014). Multimer monitoring of CMV-specific T cells in research and in clinical applications. Diagnostic Microbiology and Infectious Disease 78, 201-212. http://dx.doi.org/10.1016/j.diagmicrobio.2013.11.007

 

Gehrmann et al. Hsp70--a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck. Radiat Oncol. (2014) Jun 9;9:131 http://www.ncbi.nlm.nih.gov/pubmed/24912482

 

Gehrmann M, Cervello M, Montalto G, Cappello F, Gulino A, Knape C, Specht HM and Multhoff G (2014)Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Front. Immunol. 5:307. doi: 10.3389/fimmu.2014.00307

 

Gehrmann M, Specht HM, Bayer C, Brandstetter M, Chizzali B, Duma M, Breuninger S, Hube K, Lehnerer S, van Phi V, SageE , Schmid TE, Sedelmayr M, Schilling D, Sievert W, Stangl S and Multhoff G (2014) Hsp70 - a biomarker for tumor detection and monitoring of outcome of radiation therapy inpatients with squamous cell carcinoma of the head and neck. Radiation Oncology. 9:131.

 

Breuninger S, Erl J, Knape C, Gunther S, Regel I, et al. (2014) Quantitative Analysis of Liposomal Heat Shock Protein 70 (Hsp70) in the Blood of Tumor Patients Using a Novel Liphsp70 ELISA. J Clin Cell Immunol 5:264. doi: 10.4172/2155-9899.1000264. https://www.omicsonline.org/open-access/quantitative-analysis-of-liposomal-heat-shock-protein-hsp-in-the-blood-of-tumor-patients-2155-9899-5-264.php?aid=38483

 

Lydia Giannitrapani1 & Gabriele Multhoff .The Role of HSP70 in the Diagnosis of HCC .Forum on Immunopathological Diseases and Therapeutics, 5(3–4): 137–143 (2014). http://www.dl.begellhouse.com/journals/1a654bf03faf67ac,5749d30276266f6f,649dc7da64830b0a.html

 

Lydia Giannitrapani1 & Gabriele Multhoff .The Role of HSP70 in the Diagnosis of HCC .Forum on Immunopathological Diseases and Therapeutics, 5(3–4): 137–143 (2014). http://www.dl.begellhouse.com/journals/1a654bf03faf67ac,5749d30276266f6f,649dc7da64830b0a.html

 

Hromadnikova I et al (2013) Influence of in vitro IL-2 or IL-15 alone or in combination with Hsp-70-Derived 14-mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors. Mediators Inflamm.2013:405295. doi: 10.1155/2013/405295. Epub 2013 Feb 17.

 

Atarod S and Dickinson AM (2013) MicroRNAs: the missing link in the biology of graft-versus-host disease? Front. Immunol. 4:420. doi: 10.3389/fimmu.2013.00420. http://journal.frontiersin.org/article/10.3389/fimmu.2013.00420/full

 

Severin Zinöcker , RalfDressel , Xiao-Nong Wang , Anne M.Dickinson.Bent Rolstad. Immune reconstitution and graft-versus-host reactions in rat models of allogeneic hematopoietic cell transplantation. Frontiers of Immunology. 2012. 3;355.doi: 10.3389/fimmu.2012.00355file. htpp://campus/home/home31/nkln2/Downloads/fimmu-03-00355.pdf