Professor Gabriele Multhoff PhD
Department of Radiation Oncology,
Klinikum rechts der Isar,
Munich and HMGU Munich
Professor Dr. Gabriele Multhoff is the scientist-in-charge for Technical University Munich, an associated partner in the Celleurope project. The project role involves sharing expertise in heat shock proteins and peptides. Professor Multhoff leads the Experimental Radiooncology and Radiobiology and is also the leader of the Clinical Cooperation Group (CCG) “Innate Immunity in Tumor Biology” at the Helmholtz Zentrum München. For more than 15 years Professor Multhoff has had a research interest in the development of innovative immunotherapies based on NK cells, antibodies and enzymes that target highly aggressive Hsp70 membrane positive tumors. At the TU München, Professor Multhoff initiated a proof-of-concept phase II clinical trial to evaluate an NK cell mediated immunotherapeutic approach based on heat shock proteins (HSP) to improve clinical outcome of NSCLC patients following radio chemotherapy. Professor Multhoff's research group aims to identify a tumour-specific membrane expression of Hsp70 that correlates with an increased sensitivity to lysis mediated by NK cells in vitro and in vivo.
Research Network Team
Hanno Specht (MD)
Mathias Gehrmann (phD)
Jessica Pelzel (TA)
Sophie Gunther (MD student)
Stephie Ertl (PhD student)
Janina Erl (PhD student)
Petra Mózes (Hungary) Experienced Researcher
I studied at the University of Szeged, Faculty of Medicine, Hungary and finished my medical studies with the result "cum laude" in 2011. I attended the Clinical Doctoral School at the University of Szeged, Department of Clinical Oncology and Radiotherapy with a focus on Effect of modern radiotherapeutical methods in the treatment of children and young adults suffering from central nervous system malignancies, and I participated in small animal irradiation researches. In the frame of my doctoral study I spent a 2 months fellowship at the Heidelberg Ion-Beam Therapy Centre.
I am first author on a paper, ‘Clinical course of central neurocytoma with malignant transformation – an indication for craniospinal’ in Pathology and Oncology Research (October 2013) and co-author on two further papers, one in the Int J Radiat Biol and the other within Ideggyogy Sz.
Project Title: Determining soluble serum markers and membrane-bound NK ligands for the prediction of anti-tumour immune (GvL) responses and GvHD.
Petra completed her project as a Marie Curie Fellow in July 2015. She continues to work with Prof Multhoff and team.
1. Stangl S, Gehrmann M, Riegger J, Kuhs K, Riederer I, Sievert W, Hube K, Mocikat R, Dressel R, Kremmer E, Pockley AG, Friedrich L, Vigh L, Skerra A, Multhoff G.Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. PNAS 108 (2): 733-738, 2011.
2. Stangl S, Themelis G, Friedrich L, Ntziachristos V, Sarantopoulos A, Molls M, Skerra A, Multhoff G. Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment. Radiother Oncol. 99: 313-316, 2011.
3. Gehrmann M, Stangl S, Kirschner A, Foulds GA, Sievert W, Doß BT, Walch A, Pockley AG, Multhoff G. Immunotherapeutic Targeting of Membrane Hsp70-Expressing Tumors Using Recombinant Human Granzyme B. PlosOne 7(7): e41341, 2012.
4. Bayer C, Liebhardt ME, Schmid TE, Trajkovic-Arsic M, Hube K, Specht HM, Schilling D, Gehrmann M, Stangl S, Siveke JT, Wilkens JJ, Multhoff G. Validation of Heat Shock Protein 70 as a Tumor-Specific Biomarker for Monitoring the Outcome of Radiation Therapy in Tumor Mouse Models. Int J of Rad Oncol (3)88, 2014.
5. Sievert W, Tapio S, Breuninger S, Gaipl U, Andratschke N, Trott K-R, Multhoff G. Adhesion Molecule Expression and Function of Primary Endothelial Cells in Benign and Malignant Tissues Correlates with Proliferation. PlosOne (9)3: e91808, 2014.