Professor Eva M. Weissinger MD
Leader Laboratory of Transplantation Biology
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation
Hannover Medical School
Professor Weissinger leads the Laboratory of Transplantation Biology' , where she also serves as attending physician, since 2006. Transplantation medicine, including stem cell research and regenerative medicine, is one of three main research areas within MHH, besides infection/immunity and biomedical engineering and implants.
For the past 20 years Professor Weissinger has worked within the field of bone marrow and stem cell transplantation (HSCT), focusing on complications after allogeneic HSCT. Professor Weissinger applies new technologies, such as proteomics, to the prediction of complications after allogeneic HSCT. Her expertise lies in the prediction of acute and chronic graft-versus-host-disease (GvHD) using proteomics and in the diagnosis, monitoring and treatment of cytomegalovirus infection or reactivation (CMV) in the immunosuppressed host. She has also lead and participated in clinical trials involving herpes simplex thymidine kinase (HSVTk) transduction of donor T-cells to avoid acute GvHD, as well as generation of CMV-specific T-cells for adoptive immunotherapy.
Professor Weissinger is an active member of the EBMT, ASH, the German Hemaotology and Oncology society, and the European Hemtology Association. Within MHH she is involved in teaching at the level of graduate and postgraduate education. She is reviewer of major scientific journals in the field such as “Blood” and “Biology of Blood and Bone Marrow Transplantation”, “Leukaemia”, “Experts in proteomics” and more. Professor Weissinger's research is funded by several grants especially the German Research Foundation (DFG), the Ministry for Education and Research and the German Jose-Carreras-Leukemia foundation.
Research Network Team
Dr. Sylvia Borchers; PhD. Dr. Borchers has obtained her PhD in the Laboratory of Transplantation biology in 2008 and is working since then on the immunology of the reconstitution of viral immunity after allogeneic HSCT. She is involved in teaching student courses in immunology after HSCT.
Professor Martin Messerle. Institute of Virology, MHH. Professor Messerle is involved in CMV-oriented research and collaborates with the laboratory of transplantation biology in one additional project of CMV-associated complications after allogeneic HSCT since 2011, funded by the Ministry of Education and research.
Justyna Ogonek (Poland) Early Stage Reseacher.
Justyna Ogonek is Polish and studied biotechnology at the Jagiellonian University (Krakow). Her master thesis was aimed at the influence of metalloproteinase ADAM17 on capacity to metastasize in murine melanoma cell line (B16F10). She investigated the links between the ADAM17 protein level and changes in migration, proliferation, invasiveness of cells . During her study period, she had the opportunity to work as an Erasmus exchange student in Professor Pirjo Laakkonen group in the A.I. Virtanen Institute for Molecular Sciences in Kuopio, Finland. Whilst involved in this project, which focused on analyzing malignant glioma specific molecular markers from the patient serum samples, she also took part in summer internship organized by the Spanish National Centre for Cardiovascular Research in Madrid, with responsibility for phenotypical and functional characterization of neutrophil subpopulations in PhD Andres Hidalgo group.
Justyna's academic and professional experiences have served to highlight her continuing interests in the field of immunology.
Project Title: Monitoring CMV reactivation and use of cellular therapy products (specific T cells) for CMV infection post HSCT.
Justyna completed her project as a Marie Curie Fellow in March 2016.
1. Borchers S , Bremm M, Lehrnbecher T, Dammann E, Pabst B, Wölk B, Esser R, Yildiz M, Eder M, Stadler M, Bader P, Martin H, Jarisch A, Schneider G, Klingebiel T, Ganser A, Weissinger EM , Koehl U. Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation. PLoS One . 2012;7(12):e50248. doi: 10.1371/journal.pone.0050248. Epub 2012 Dec 13
2. Borchers S , Weissinger EM , Pabst B, Ganzenmueller T, Dammann E, Luther S, Diedrich H, Ganser A and Stadler M. Expansion of recipient-derived antiviral T cells may influence donor chimerism after allogeneic stem cell transplantation. Transpl. Infect. Disease 2012 in press 2013
3. Daenthanasanmak A, Salguero G, Borchers S , Figueiredo C, Jacobs R, Sundarasetty BS, Schneider A, Schambach A, Eiz-Vesper B, Blasczyk R, Weissinger EM , Ganser A, Stripecke R. Integrase-defective lenti viral vectors encoding cytokines induce differentiation of human dendritic cells and stimulate multivalent immune responses in vitro and in vivo. Vaccine . 2012 Jul 20;30(34):5118-31.
4. Borchers S , Luther S, Lips U, Hahn N, Kontsendorn J, Stadler M, Buchholz S, Diedrich H, Eder M, Koehl U, Ganser A, Mischak- Weissinger E . Tetramer monitoring to assess risk factors for recurrent cytomegalovirus reactivation and reconstitution of antiviral immunity post allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis . 2011 Jun;13(3):222-36.